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The chemical 2C-H, as well as 2C-I and 2C-B, is synthesized by the eminent chemist Alexander Shulgin. The drug 2C-H belongs to phenylethylamines, in particular to their group 2C. It is known that if it enters the human body, the substance 2C-H (trip) produces psychoactive effects. Precise data on the dosage and its effect ratio per person are still absent. The preparation 2C-H (reviews) is mainly used for pharmaceutical purposes BUY 2C-H.
2C-H is used as a precursor in the synthesis of other substituted phenethylamines such as 2C-B, 2C-I, and 2C-N. 2C-H has been found in trace amounts by the DEA’s south-central laboratory in tablets that were suspected of containing MDMA
There is no record of 2C-H trials in humans, as it would likely be destroyed by monoamine oxidase enzymes before causing any significant psychoactive effects. In the book PiHKAL, Alexander Shulgin lists both the dosage and duration of 2C-H effects as unknown. Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-H.
2C-H exhibits agonist activity in vitro at human trace amine-associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization. 2C-H was found to be inactive in NCI In Vivo Anticancer Drug Screens for tumor model L1210 Leukemia. It was found to be an active Alpha-1 adrenergic receptor agonist in rabbit ear arteries. It has a binding affinity towards 5-HT2C and 5-HT2A receptors in rats. It features competitive antagonist activity at 5-HT serotonin receptor in Sprague-Dawley rat stomachs. It exhibits binding affinity against rat 5-hydroxytryptamine 2C receptors using [3H]mesulergine as a radioligand.